Ophthalmic Assessments for Systemic Drug Trials

Independent Ocular Safety Monitoring

Many systemic therapies require expert ophthalmic evaluation to monitor potential ocular adverse effects and ensure participant safety throughout a clinical trial.

We provide independent ophthalmic assessments and ocular safety monitoring services for sponsors and CROs conducting clinical research across a broad range of therapeutic areas.

Our team works alongside research sites, hospitals and clinical trial networks to deliver standardised ophthalmic evaluations, imaging and safety assessments that support protocol requirements and regulatory obligations.

Supporting Ocular Safety Endpoints

Systemic therapies can affect visual function, the retina, optic nerve, ocular surface and other ocular structures.

We provide comprehensive ophthalmic assessments to support:

  • Baseline ocular evaluations
  • Ongoing ocular safety monitoring
  • Protocol-specific ophthalmic endpoints
  • Adverse event investigations
  • Drug toxicity surveillance
  • Specialist ophthalmic referrals and follow-up

Our assessments help sponsors identify, monitor and document potential ocular effects throughout the study lifecycle.

Ophthalmic Assessment Services

We offer a comprehensive range of ophthalmic examinations and diagnostic assessments, including:

Comprehensive Eye Examinations

  • Best corrected visual acuity
  • Refraction
  • Slit lamp examination
  • Intraocular pressure measurement
  • Dilated fundus examination

Retinal and Posterior Segment Assessments

  • Retinal examinations
  • Diabetic eye assessments
  • Macular evaluations
  • Optic nerve assessments
  • Retinal pathology review

Functional Vision Assessments

  • Visual field testing (Perimetry)
  • Colour vision assessment
  • Contrast sensitivity testing
  • Protocol-specific visual function testing

Advanced Ocular Imaging

  • Optical Coherence Tomography (OCT) using Heidelberg Spectralis
  • Fundus AutoFluorescence
  • Fundus photography
  • Anterior segment imaging
  • Corneal topography and tomography
  • Additional protocol-specific imaging assessments

Therapeutic Areas Supported

We support sponsors and CROs conducting clinical trials across a wide range of therapeutic areas where ocular monitoring may be required.

Oncology

Targeted therapies, immunotherapies and emerging cancer treatments increasingly require ocular safety monitoring throughout treatment and follow-up.

Neurology

Neurological therapies may require assessment of visual pathways, retinal health and visual function endpoints.

Endocrinology

Clinical trials involving diabetes and metabolic disorders often require retinal and diabetic eye assessments (e.g. fundus photography and retinal assessments) as part of participant monitoring.

Rheumatology and Immunology

Long-term therapies and biologic agents may require ongoing ophthalmic surveillance to identify potential ocular adverse effects.

Rare Disease and Gene Therapy

Novel therapies frequently incorporate specialised ophthalmic assessments as part of safety and efficacy monitoring programs.

Flexible Assessment Models

Our team can support clinical research through a range of service models, including:

  • Subcontracted ophthalmic assessments
  • Referral-based participant evaluations
  • Specialist endpoint assessments
  • Ocular safety monitoring programs
  • Independent ophthalmic reviews

We work collaboratively with sponsors, CROs and primary research sites to ensure assessments are performed consistently and in accordance with study protocols.

Partner With Our Ophthalmic Assessment Team

If your clinical trial requires independent ophthalmic evaluations, retinal monitoring or ocular safety assessments, we would welcome the opportunity to discuss your protocol requirements.

contact our clinical research team to discuss study feasibility, assessment capabilities and site partnership opportunities